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Follistatin, recognized as an activin-binding protein, is encoded in humans by the FST gene. This autocrine glycoprotein is expressed across a wide array of tissues in higher animals, showcasing its universal presence and importance. Its main role is to bind to and neutralize members of the TGF-β superfamily, with a particular emphasis on activin, which functions as a paracrine hormone.
Initially identified as FSH-suppressing protein (FSP), follistatin was discovered in follicular fluid for its ability to inhibit the secretion of follicle-stimulating hormone (FSH) by the anterior pituitary gland. This early identification highlighted its significant role in reproductive health and its broader regulatory functions within the body.
This information is provided to offer a comprehensive understanding based on scientific research and is intended for educational purposes. As with all scientific and health-related topics, consulting with a healthcare professional is advisable when considering the implications of such proteins for health and disease management.